The incidence of serious adverse events was numerically higher with febuxostat than with placebo, but the difference between treatments was not statistically significant.
非布索坦组严重不良反应在数量上多于安慰剂组，但是没有统计学上的显著性差异。
2
Results The key intermediate 4 for the synthesis of febuxostat was synthesized via a four-step procedure in a total yield of 22.6% and its structure was confirmed by 1H-NMR and ESI-MS.