Malainey et al. find a possible explanation in late-eighteenth and early-nineteenth century accounts from three frontiersmen who had adapted to lean-meat diets during extended periods in the plains.
Dr Brüning found himself wondering if such resistance extended to insulin-regulated cells in the brain, and whether that might be an explanation for the inappropriate appetites of the obese.
Dr Brünin想知道这种阻抗不回应是不是也延伸到调节胰岛素的脑细胞，从而解释何以肥胖症患者常有食欲异常。