Because of limitations of in vitro replication systems, studies of HCV pathogenesis have been limited to observation of natural infection of humans and experimental infection of chimpanzees.
The experimental animal model has typical pathologic manifestation and good replication and can be used to study the effect of drugs.
该实验动物模型具有典型的病理改变和很好的重复性，可用于药效学研究工作。
3
He showed that the matter of fact was an artifact, the replication was a process of negotiation and the win of experimental method was closely related to the social interests.