Allopurinol can enhance cardiac function by improving unbalanced distribution of calcium, increase the sensitivity of myofilaments to calcium and improving abnormal excitationcontractioncoupling.
Cardiac calcium signal plays an important role in excitation-contractioncoupling. It is also associated with developing mechanisms of atrial fibrillation.
心肌钙信号在心肌细胞兴奋-收缩耦联中起着重要作用，它和心房颤动发生机制有关。
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Trabeculae from the right ventricle of mice were dissected for assessment of changes in excitation-contractioncoupling.