Definition of topoisomer in English:

topoisomer

nounˌtɒpəʊˈʌɪsəməˌtäpōˈīsəmər

Biochemistry

A topologically distinct isomer, especially of DNA.
〔生化〕拓扑异构体
Example sentencesExamples
- An extract was deemed to be deficient if, in all three trials, the ratio of intermediate to supercoiled products indicated an accumulation of intermediate topoisomers (compared to wild type).
- The distribution of 2 plasmid DNA topoisomers was measured by Southern blot analysis with a radiolabeled 2 DNA probe.
- Comparing the topoisomer distribution of plasmid DNA from the ancestor with the completely relaxed plasmid control yielded an estimate of = - 0.066 for the ancestor.
- This suggests that the main contribution to the variation in adjusted parameters comes from the presence of a distribution in topoisomers rather than thermal fluctuations.
- The 9C 14 loop was observed to give a mixture of a relaxed topoisomer, a positive supercoil, and a small amount of negative supercoil upon ring closure, whereas 11C12 gave mainly a relaxed topoisomer.
- In the sequence used here, the presence of L-Gln residues may lead to topoisomers.

Definition of topoisomer in US English:

topoisomer

nounˌtäpōˈīsəmər

Biochemistry

A topologically distinct isomer, especially of DNA.
〔生化〕拓扑异构体
Example sentencesExamples
- The distribution of 2 plasmid DNA topoisomers was measured by Southern blot analysis with a radiolabeled 2 DNA probe.
- An extract was deemed to be deficient if, in all three trials, the ratio of intermediate to supercoiled products indicated an accumulation of intermediate topoisomers (compared to wild type).
- The 9C 14 loop was observed to give a mixture of a relaxed topoisomer, a positive supercoil, and a small amount of negative supercoil upon ring closure, whereas 11C12 gave mainly a relaxed topoisomer.
- This suggests that the main contribution to the variation in adjusted parameters comes from the presence of a distribution in topoisomers rather than thermal fluctuations.
- Comparing the topoisomer distribution of plasmid DNA from the ancestor with the completely relaxed plasmid control yielded an estimate of = - 0.066 for the ancestor.
- In the sequence used here, the presence of L-Gln residues may lead to topoisomers.

单词	topoisomer
释义	Definition of topoisomer in English: topoisomer nounˌtɒpəʊˈʌɪsəməˌtäpōˈīsəmər Biochemistry A topologically distinct isomer, especially of DNA. 〔生化〕拓扑异构体 Example sentencesExamples An extract was deemed to be deficient if, in all three trials, the ratio of intermediate to supercoiled products indicated an accumulation of intermediate topoisomers (compared to wild type). The distribution of 2 plasmid DNA topoisomers was measured by Southern blot analysis with a radiolabeled 2 DNA probe. Comparing the topoisomer distribution of plasmid DNA from the ancestor with the completely relaxed plasmid control yielded an estimate of = - 0.066 for the ancestor. This suggests that the main contribution to the variation in adjusted parameters comes from the presence of a distribution in topoisomers rather than thermal fluctuations. The 9C 14 loop was observed to give a mixture of a relaxed topoisomer, a positive supercoil, and a small amount of negative supercoil upon ring closure, whereas 11C12 gave mainly a relaxed topoisomer. In the sequence used here, the presence of L-Gln residues may lead to topoisomers. Definition of topoisomer in US English: topoisomer nounˌtäpōˈīsəmər Biochemistry A topologically distinct isomer, especially of DNA. 〔生化〕拓扑异构体 Example sentencesExamples The distribution of 2 plasmid DNA topoisomers was measured by Southern blot analysis with a radiolabeled 2 DNA probe. An extract was deemed to be deficient if, in all three trials, the ratio of intermediate to supercoiled products indicated an accumulation of intermediate topoisomers (compared to wild type). The 9C 14 loop was observed to give a mixture of a relaxed topoisomer, a positive supercoil, and a small amount of negative supercoil upon ring closure, whereas 11C12 gave mainly a relaxed topoisomer. This suggests that the main contribution to the variation in adjusted parameters comes from the presence of a distribution in topoisomers rather than thermal fluctuations. Comparing the topoisomer distribution of plasmid DNA from the ancestor with the completely relaxed plasmid control yielded an estimate of = - 0.066 for the ancestor. In the sequence used here, the presence of L-Gln residues may lead to topoisomers.
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