So as to be without or beyond all remedy; to a remediless degree.
Mid 16th century; earliest use found in John Olde (d. 1557), translator and religious controversialist. From remediless + -ly.
英汉双解词典包含464360条英汉词条，基本涵盖了全部常用单词的翻译及用法，是英语学习的有利工具。