The switching off of the expression of a gene, for example by the introduction of an antisense RNA that blocks translation of the messenger RNA.
基因沉默，切断基因显现
Example sentencesExamples
This outcome is in contrast to that with sex-specific differences in selection, which can cause extreme differences in gene expression and even gene silencing.
It suggests novel roles for transcription factors in repression and furthers our knowledge of alternative mechanisms of gene silencing in yeast.
Sequence specific triplex formation can be applied for gene targeting, gene silencing and mutagenesis.
We suspect that there is a system in humans that causes gene silencing, but we don't know the mechanism yet.
This idea was supported by the observation that inverted-repeat sequences could induce gene silencing in plants and in C. elegans.
It is shown that a mechanism of gene silencing was responsible for the lack of expression of the transgene and its lack of effects on nitrate contents in lettuce leaves.
Polyploidization can induce a flurry of genetic and epigenetic events that include DNA sequence elimination and gene silencing.
Consistent with the hypothesized gene silencing, the level of reporter expression in transgenic strains carrying multicopy arrays is rarely a simple multiple of expression observed with rare single-copy integration events.
Duplicate gene expression is common, as rates of gene silencing are much lower than predicted by traditional models.
The antisense or co-supression of gene expression, collectively known as post-transcriptional gene silencing, has been particularly versatile and powerful in studies of plant metabolism.
A number of studies have attempted to address this relationship as well as the role of somatic pairing in gene silencing.
In cotton, uniparental gene silencing was observed to switch during development and affected both recent and established allopolyploids.
Such mutants have been generated by chemical mutagenesis, gene disruption, and antisense gene silencing.
How is gene silencing or activation established and maintained?
The organization of DNA into euchromatin and heterochromatin is implicated in gene silencing.
It is also possible that small RNAs and RNA interference play a role in gene silencing in polyploids.