Definition of prodrug in English:

prodrug

noun ˈprəʊdrʌɡˈprōˌdrəɡ

A biologically inactive compound which can be metabolized in the body to produce a drug.
药物前体，前药
Example sentencesExamples
- This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death.
- Bouncing powerful X-rays off the protein crystals yielded a three-dimensional image of the dual protein structure, showing them exactly how the prodrug and the enzyme interact.
- It is a prodrug that is converted intracellularly to various metabolites that bind to the enzyme thymidylate synthase, inhibiting synthesis of thymidine, DNA, and RNA.
- As the prodrug is metabolically converted to its cytotoxic form, it penetrates the cell bearing the bound enzyme as well as ‘naked’ cells that are nearby.
- An ester prodrug was shown to increase the bioavailability of MPA following oral administration.
- The use of targeting antibodies conjugated to enzymes that selectively activate antineoplastic prodrugs on or near cancer cells (known as antibody-directed enzyme prodrug therapy, or ADEPT) is also addressed.
- At Cardiff, she is promoting a more proactive role for polymers: ‘as integral parts of therapeutics, which could be thought of as macromolecular prodrugs, or even as drugs in their own right’.
- The antihistamine loratidine is one example of a prodrug that must be activated by liver enzymes to be effective, the researchers pointed out in their paper.
- Valacyclovir, a prodrug that metabolizes to acyclovir, has better bioavailability and requires less frequent dosing than acyclovir.
- They waited a bit to give the unbound nanobodies time to filter out of the body, then injected the prodrug.
- The improvement of bioavailability of ALA by application of ALA esters is determined by two processes: the rate of diffusion of the prodrug through the cell membrane and its rate of enzymatic conversion into ALA.
- The influence of branching on the enzymatic stability of the compounds was investigated, as it is known that sterically hindered ester prodrugs are more stable toward enzymatic hydrolysis.
- ALA is a prodrug and is being used as a photodynamic diagnosis agent in head and neck cancers.
- Cefuroxime axetil is the ester prodrug of cefuroxime sodium, suitable for oral administration.
- Codeine, a prodrug, depends on P450 metabolism to morphine for its analgesic effect.
- Here the enzyme lays dormant until non-toxic drugs, called prodrugs, are given.
- In summary, this study has confirmed quantitatively the considerable degree to which the delivery of the ALA prodrug can be enhanced by iontophoresis of the simple, cationic alkyl esters at neutral pH.
- A second important aspect of the invention is to have the second binding head capture or contain an enzyme that activates a prodrug substrate.
- In addition, the drugs which can increase GSH content, such as cysteine prodrugs, will also reduce acetaminophen hepatotoxicity.
- While remaining innocuous to the normal tissues, the prodrug is converted to the cytotoxin by the enzyme localised at the tumour.

Definition of prodrug in US English:

prodrug

nounˈprōˌdrəɡ

A biologically inactive compound which can be metabolized in the body to produce a drug.
药物前体，前药
Example sentencesExamples
- In addition, the drugs which can increase GSH content, such as cysteine prodrugs, will also reduce acetaminophen hepatotoxicity.
- Codeine, a prodrug, depends on P450 metabolism to morphine for its analgesic effect.
- ALA is a prodrug and is being used as a photodynamic diagnosis agent in head and neck cancers.
- Valacyclovir, a prodrug that metabolizes to acyclovir, has better bioavailability and requires less frequent dosing than acyclovir.
- The influence of branching on the enzymatic stability of the compounds was investigated, as it is known that sterically hindered ester prodrugs are more stable toward enzymatic hydrolysis.
- In summary, this study has confirmed quantitatively the considerable degree to which the delivery of the ALA prodrug can be enhanced by iontophoresis of the simple, cationic alkyl esters at neutral pH.
- This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death.
- An ester prodrug was shown to increase the bioavailability of MPA following oral administration.
- While remaining innocuous to the normal tissues, the prodrug is converted to the cytotoxin by the enzyme localised at the tumour.
- As the prodrug is metabolically converted to its cytotoxic form, it penetrates the cell bearing the bound enzyme as well as ‘naked’ cells that are nearby.
- A second important aspect of the invention is to have the second binding head capture or contain an enzyme that activates a prodrug substrate.
- They waited a bit to give the unbound nanobodies time to filter out of the body, then injected the prodrug.
- Here the enzyme lays dormant until non-toxic drugs, called prodrugs, are given.
- The improvement of bioavailability of ALA by application of ALA esters is determined by two processes: the rate of diffusion of the prodrug through the cell membrane and its rate of enzymatic conversion into ALA.
- It is a prodrug that is converted intracellularly to various metabolites that bind to the enzyme thymidylate synthase, inhibiting synthesis of thymidine, DNA, and RNA.
- The use of targeting antibodies conjugated to enzymes that selectively activate antineoplastic prodrugs on or near cancer cells (known as antibody-directed enzyme prodrug therapy, or ADEPT) is also addressed.
- At Cardiff, she is promoting a more proactive role for polymers: ‘as integral parts of therapeutics, which could be thought of as macromolecular prodrugs, or even as drugs in their own right’.
- Cefuroxime axetil is the ester prodrug of cefuroxime sodium, suitable for oral administration.
- The antihistamine loratidine is one example of a prodrug that must be activated by liver enzymes to be effective, the researchers pointed out in their paper.
- Bouncing powerful X-rays off the protein crystals yielded a three-dimensional image of the dual protein structure, showing them exactly how the prodrug and the enzyme interact.

单词	prodrug
释义	Definition of prodrug in English: prodrug noun ˈprəʊdrʌɡˈprōˌdrəɡ A biologically inactive compound which can be metabolized in the body to produce a drug. 药物前体，前药 Example sentencesExamples This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death. Bouncing powerful X-rays off the protein crystals yielded a three-dimensional image of the dual protein structure, showing them exactly how the prodrug and the enzyme interact. It is a prodrug that is converted intracellularly to various metabolites that bind to the enzyme thymidylate synthase, inhibiting synthesis of thymidine, DNA, and RNA. As the prodrug is metabolically converted to its cytotoxic form, it penetrates the cell bearing the bound enzyme as well as ‘naked’ cells that are nearby. An ester prodrug was shown to increase the bioavailability of MPA following oral administration. The use of targeting antibodies conjugated to enzymes that selectively activate antineoplastic prodrugs on or near cancer cells (known as antibody-directed enzyme prodrug therapy, or ADEPT) is also addressed. At Cardiff, she is promoting a more proactive role for polymers: ‘as integral parts of therapeutics, which could be thought of as macromolecular prodrugs, or even as drugs in their own right’. The antihistamine loratidine is one example of a prodrug that must be activated by liver enzymes to be effective, the researchers pointed out in their paper. Valacyclovir, a prodrug that metabolizes to acyclovir, has better bioavailability and requires less frequent dosing than acyclovir. They waited a bit to give the unbound nanobodies time to filter out of the body, then injected the prodrug. The improvement of bioavailability of ALA by application of ALA esters is determined by two processes: the rate of diffusion of the prodrug through the cell membrane and its rate of enzymatic conversion into ALA. The influence of branching on the enzymatic stability of the compounds was investigated, as it is known that sterically hindered ester prodrugs are more stable toward enzymatic hydrolysis. ALA is a prodrug and is being used as a photodynamic diagnosis agent in head and neck cancers. Cefuroxime axetil is the ester prodrug of cefuroxime sodium, suitable for oral administration. Codeine, a prodrug, depends on P450 metabolism to morphine for its analgesic effect. Here the enzyme lays dormant until non-toxic drugs, called prodrugs, are given. In summary, this study has confirmed quantitatively the considerable degree to which the delivery of the ALA prodrug can be enhanced by iontophoresis of the simple, cationic alkyl esters at neutral pH. A second important aspect of the invention is to have the second binding head capture or contain an enzyme that activates a prodrug substrate. In addition, the drugs which can increase GSH content, such as cysteine prodrugs, will also reduce acetaminophen hepatotoxicity. While remaining innocuous to the normal tissues, the prodrug is converted to the cytotoxin by the enzyme localised at the tumour. Definition of prodrug in US English: prodrug nounˈprōˌdrəɡ A biologically inactive compound which can be metabolized in the body to produce a drug. 药物前体，前药 Example sentencesExamples In addition, the drugs which can increase GSH content, such as cysteine prodrugs, will also reduce acetaminophen hepatotoxicity. Codeine, a prodrug, depends on P450 metabolism to morphine for its analgesic effect. ALA is a prodrug and is being used as a photodynamic diagnosis agent in head and neck cancers. Valacyclovir, a prodrug that metabolizes to acyclovir, has better bioavailability and requires less frequent dosing than acyclovir. The influence of branching on the enzymatic stability of the compounds was investigated, as it is known that sterically hindered ester prodrugs are more stable toward enzymatic hydrolysis. In summary, this study has confirmed quantitatively the considerable degree to which the delivery of the ALA prodrug can be enhanced by iontophoresis of the simple, cationic alkyl esters at neutral pH. This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death. An ester prodrug was shown to increase the bioavailability of MPA following oral administration. While remaining innocuous to the normal tissues, the prodrug is converted to the cytotoxin by the enzyme localised at the tumour. As the prodrug is metabolically converted to its cytotoxic form, it penetrates the cell bearing the bound enzyme as well as ‘naked’ cells that are nearby. A second important aspect of the invention is to have the second binding head capture or contain an enzyme that activates a prodrug substrate. They waited a bit to give the unbound nanobodies time to filter out of the body, then injected the prodrug. Here the enzyme lays dormant until non-toxic drugs, called prodrugs, are given. The improvement of bioavailability of ALA by application of ALA esters is determined by two processes: the rate of diffusion of the prodrug through the cell membrane and its rate of enzymatic conversion into ALA. It is a prodrug that is converted intracellularly to various metabolites that bind to the enzyme thymidylate synthase, inhibiting synthesis of thymidine, DNA, and RNA. The use of targeting antibodies conjugated to enzymes that selectively activate antineoplastic prodrugs on or near cancer cells (known as antibody-directed enzyme prodrug therapy, or ADEPT) is also addressed. At Cardiff, she is promoting a more proactive role for polymers: ‘as integral parts of therapeutics, which could be thought of as macromolecular prodrugs, or even as drugs in their own right’. Cefuroxime axetil is the ester prodrug of cefuroxime sodium, suitable for oral administration. The antihistamine loratidine is one example of a prodrug that must be activated by liver enzymes to be effective, the researchers pointed out in their paper. Bouncing powerful X-rays off the protein crystals yielded a three-dimensional image of the dual protein structure, showing them exactly how the prodrug and the enzyme interact.
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