Definition of proband in English:

proband

noun ˈprəʊbəndˈprōˌband

Genetics Medicine

A person serving as the starting point for the genetic study of a family.
（尤用于医学与精神病学）渊源者，先证者；基人（作为家庭遗传研究起源的人）
Example sentencesExamples
- Our study was a family-based study and included probands with asthma from two populations, Puerto Ricans and Mexicans.
- A genetic basis to the disorder is borne out by risk increasing with genetic proximity to the proband.
- Furthermore, all these approaches are unable to handle trios with missing genotypic information on the proband and these families are typically excluded from the analysis.
- Only offspring of both parents were included in the analysis, but birth order was defined by using all the mother's offspring, including both full and half siblings of the study proband.
- Most data sets utilized in the study of hereditary diseases are constructed around probands, making correction for ascertainment bias necessary; this set of data is no exception.

Origin

1920s: from Latin probandus 'to be proved', gerundive of probare 'to test'.

Definition of proband in US English:

proband

nounˈprōˌband

Genetics Medicine

A person serving as the starting point for the genetic study of a family (used especially in medicine and psychiatry).
（尤用于医学与精神病学）渊源者，先证者；基人（作为家庭遗传研究起源的人）
Example sentencesExamples
- Furthermore, all these approaches are unable to handle trios with missing genotypic information on the proband and these families are typically excluded from the analysis.
- A genetic basis to the disorder is borne out by risk increasing with genetic proximity to the proband.
- Our study was a family-based study and included probands with asthma from two populations, Puerto Ricans and Mexicans.
- Only offspring of both parents were included in the analysis, but birth order was defined by using all the mother's offspring, including both full and half siblings of the study proband.
- Most data sets utilized in the study of hereditary diseases are constructed around probands, making correction for ascertainment bias necessary; this set of data is no exception.

Origin

1920s: from Latin probandus ‘to be proved’, gerundive of probare ‘to test’.

单词	proband
释义	Definition of proband in English: proband noun ˈprəʊbəndˈprōˌband Genetics Medicine A person serving as the starting point for the genetic study of a family. （尤用于医学与精神病学）渊源者，先证者；基人（作为家庭遗传研究起源的人） Example sentencesExamples Our study was a family-based study and included probands with asthma from two populations, Puerto Ricans and Mexicans. A genetic basis to the disorder is borne out by risk increasing with genetic proximity to the proband. Furthermore, all these approaches are unable to handle trios with missing genotypic information on the proband and these families are typically excluded from the analysis. Only offspring of both parents were included in the analysis, but birth order was defined by using all the mother's offspring, including both full and half siblings of the study proband. Most data sets utilized in the study of hereditary diseases are constructed around probands, making correction for ascertainment bias necessary; this set of data is no exception. Origin 1920s: from Latin probandus 'to be proved', gerundive of probare 'to test'. Definition of proband in US English: proband nounˈprōˌband Genetics Medicine A person serving as the starting point for the genetic study of a family (used especially in medicine and psychiatry). （尤用于医学与精神病学）渊源者，先证者；基人（作为家庭遗传研究起源的人） Example sentencesExamples Furthermore, all these approaches are unable to handle trios with missing genotypic information on the proband and these families are typically excluded from the analysis. A genetic basis to the disorder is borne out by risk increasing with genetic proximity to the proband. Our study was a family-based study and included probands with asthma from two populations, Puerto Ricans and Mexicans. Only offspring of both parents were included in the analysis, but birth order was defined by using all the mother's offspring, including both full and half siblings of the study proband. Most data sets utilized in the study of hereditary diseases are constructed around probands, making correction for ascertainment bias necessary; this set of data is no exception. Origin 1920s: from Latin probandus ‘to be proved’, gerundive of probare ‘to test’.
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