Weary, fatigued, exhausted.
Early 17th century; earliest use found in William Martyn (bap. 1562, d. 1617), lawyer and historian. From defatigate + -ed.
英汉双解词典包含464360条英汉词条，基本涵盖了全部常用单词的翻译及用法，是英语学习的有利工具。