re·frac·to·ry /rɪˈfræktəri/ adjectiveadj 1. formalDISOBEY deliberately not obeying someone in authority and being difficult to deal with or control 难驾驭的,不服管教的 SYN unruly
2. medical a refractory disease or illness is hard to treat or cure 〔疾病〕难以医治的;难以治愈的